Most sedating antidepressants
Abuse may lead to severe psychological or physical dependence.Has a potential for abuse less than those in schedules 1 and 2.
Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above.
In 1996, the two drugs mentioned most frequently for the treatment of insomnia were trazodone, a sedating tricyclic antidepressant (TCA), and zolpidem, a non-benzodiazepine hypnotic. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders.
Trazodone is indicated for the treatment of depression, but not specifically labeled for use as a hypnotic.
The type of sleep disturbance produced by depression pharmacotherapy varies based on the compound’s mechanism of action and the dosage employed. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M.
Effects may include decrements in rapid eye movement (REM) sleep, a lengthening of the time to sleep onset, and an increase in nocturnal arousals (Table 1). Ventricular arrhythmias possibly aggravated by trazodone.